Daniel P. Petrylak, MD, Professor of Medicine, Co-Leader of Prostate Cancer, Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, discusses the new isotope agent radium-223 (Alpharadin).

The ALpharadin in SYMptomatic Prostate CAncer (ALSYMPCA) trial that investigated radium-223 for prostate cancer with bone metastases was the first trial to demonstrate an overall survival benefit for an isotopic agent. This agent is set apart by its tolerability when combined with hormonal therapies and chemotherapy.

Radium-233 combines well with docetaxel, something that sets it apart from other approved radiopharmaceuticals. The ALSYMPCA trial investigated the agent in patients that were post -- or deemed unfit to receive docetaxel.

Further studies need to be done to determine how to sequence these drugs in a manner that creates a minimum amount of toxicities.

• Dr. Petrylak Discusses the Isotope Radium-223 ( Download)
• Dr. Petrylak Discusses Sequencing Prostate Cancer Therapies ( Download)
• Dr. Sartor Discusses the Novel Agent Radium-223 ( Download)
• ASCO 2013 - Øyvind Bruland, M.D, Ph.D., discusses Xofigo (radium Ra 223 dichloride) ( Download)
• Dr. Petrylak on PSMA ADC for Patients with mCRPC ( Download)
• Dr. Daniel Petrylak Discusses Novel Bone Targeted Therapies in Prostate Cancer ( Download)
• Dr. George Discusses Radium-223 for Patients With mCRPC Part I ( Download)
• Dr. Shore Discusses Patient Considerations With Radium-223 ( Download)
• Dr. Petrylak Explains Prostate Cancer Clinical Trial Difficulties ( Download)
• Dr. Daniel Petrylak on Biomarker Discovery in Advanced Prostate Cancer ( Download)
• Dr. Petrylak Discusses Custirsen as a Potential Treatment for Prostate Cancer ( Download)
• Dr. Petrylak on the STRIDE Study: Concurrent vs Sequential Enzalutamide With Sipuleucel-T for mCRPC ( Download)
• ASCO 2013 - Gillies O'Bryan-Tear M.D., Xofigo (radium Ra 223 dichloride) ( Download)
• Dr. Dreicer on Challenges of Radium-223 in Prostate Cancer ( Download)
• Dr. Daniel Petrylak Discusses Chemotherapy in Prostate Cancer ( Download)